CFB week 6 features some great betting lines across us sports betting apps and our expert Pauly McGuire is again back with his best picks for this rounds games.
Best College Football Picks Against the Spread Week 6
| CFB Week 6 Game | Pick Against the Spread |
|---|---|
| #4 Tennessee at Arkansas | Tennessee -13.5 |
| #8 Miami at California | Cal +12 |
| #9 Missouri at #25 Texas A&M | Missouri +2 |
| #10 Michigan at Washington | Michigan +2.5 |
| #11 USC at Minnesota | Minnesota +9.5 |
| #12 Ole Miss at South Carolina | Ole Miss -9 |
| Utah State at #21 Boise State | Over 65.5 |
| #23 Indiana at Northwestern | Indiana -13 |
| Navy at Air Force | Navy -9.5 |
#4 Tennessee (4-0) at Arkansas (3-2)
- Betting Line: Tennessee -13.5, Total 60 o/u
- Pick: Tennessee -13.5
Tennessee’s stifling defense (7.0 ppg) is ranked #2 and often overlooked due to their juggernaut offense (54.0 ppg), which is ranked #1. Star running back Dylan Sampson leads a lethal rushing attack (290 yards per game) that is ranked #4 overall. Sampson has scored 10 touchdowns and averages 6.5 yards per carry. Arkansas has one of the worst run defenses in the NCAA, allowing 234 yards per game, making Tennessee a strong pick to cover the spread.
#8 Miami (5-0) at Cal (3-1)
- Betting Line: Miami -12.5, Total 54.5 o/u
- Pick: Cal +12.5
Cal had a bye last week, giving them two weeks to prepare for Miami and quarterback Cam Ward. Ward is a Heisman Trophy contender, having thrown 18 touchdowns this season, 12 of which came in his last three games. Cal’s defense ranks #12 in scoring (12.8 ppg), and they will look to contain Ward in what could be a low-scoring affair.
#9 Missouri (4-0) at #25 Texas A&M (4-1)
- Betting Line: Texas A&M -2, Total 48.5 o/u
- Pick: Missouri +2
Undefeated Missouri had extra preparation time coming off a bye week. Despite struggling against Boston College and narrowly defeating Vanderbilt in double overtime, Missouri shut out both Murray State and Buffalo. Texas A&M, on the other hand, is 1-4 ATS and struggled to cover spreads in recent victories, making Missouri a favorable pick as a +2 underdog.
#10 Michigan (4-1) at Washington (3-2)
- Betting Line: Washington -2.5, Total 41.5 o/u
- Pick: Michigan +2.5
Washington has lost two of their last three games, struggling offensively (18.5 ppg). Michigan relies on a strong rushing attack (195 yards per game), led by Kalel Mullings, who averages 7.0 yards per carry. With new quarterback Ax Orji leading Michigan’s revamped offense, they have won their last two games and look to cover and win outright as a +2.5 road underdog.
#11 USC (3-1) at Minnesota (2-3)
- Betting Line: USC -9, Total 50.5 o/u
- Pick: Minnesota +9
Minnesota, a strong defensive team (15.4 ppg), has lost three games by a combined total of five points. While USC is the better team on paper, head coach Lincoln Riley’s 8-18 ATS record as a road favorite could play into Minnesota’s favor, making them a good bet as a +9 underdog at home.
#12 Ole Miss (4-1) at South Carolina (3-1)
- Betting Line: Ole Miss -9, Total 53 o/u
- Pick: Ole Miss -9
Ole Miss, coming off a loss to Kentucky, is expected to bounce back against South Carolina. Their defense (8.4 ppg) ranks fifth in the nation, while their offense (47.4 ppg) is explosive. Quarterback Jaxson Dart will be looking for a strong performance to re-enter the Heisman Trophy race.
#15 Clemson (3-1) at FSU (1-4)
- Betting Line: Clemson -14, Total 48 o/u
- Pick: Clemson -14
Clemson has responded to a loss against Georgia with three commanding wins, outscoring opponents by an average of 32 points per game. With FSU struggling this season and being 1-4 ATS, Clemson’s strong form makes them a solid pick to cover a two-touchdown spread.
Utah State (1-3) at #21 Boise State (3-1)
- Betting Line: Boise State -27.5, Total 65.5 o/u
- Pick: Over 65.5
Boise State’s high-scoring offense (47.8 ppg) and Utah State’s poor rush defense set the stage for a potential blowout. Boise State’s Ashton Jeanty, who averages 10.3 yards per carry, will look to dominate once again, making the over 65.5 a favorable pick.
#23 Indiana (5-0) at Northwestern (2-2)
- Betting Line: Indiana -13, Total 41.5 o/u
- Pick: Indiana -13
Indiana’s balanced team (48.8 ppg offense, 13.0 ppg defense) remains undefeated and has covered the spread in four out of five games. Northwestern’s anemic offense (17 ppg) will likely struggle against Indiana’s top defense, making Indiana a strong pick to cover.
Navy (4-0) at Air Force (1-3)
- Betting Line: Navy -9.5, Total 35.5 o/u
- Pick: Navy -9.5
Navy’s strong offense (49.0 ppg) led by QB Blake Horvath will look to capitalize against Air Force’s struggling team. Horvath, with his dual-threat capabilities, is expected to dominate both on the ground and through the air, making Navy the top pick to cover the spread against their academy rival.
